Sunday, February 25, 2024

Hormone Imbalance And Autoimmune Disorders

Heal Your Gut To Balance Hormones:

779: Living With AutoImmune Diseases, Hormone Imbalances and Gut Dysfunction With Evie Takacs

Probiotics and prebiotics help balance your microbiome, which in turn helps with overall hormone balance, including optimizing thyroid function, lowering cortisol, increasing serotonin production, and even raising vitamin D levels.

It may also be wise to take things like digestive enzymes with your meals to take stress off of the gut and the digestion process. For many individuals, replacing a solid food meal with a high quality protein shake can also reduce stress on the intestinal lining and improve gut function.

Inflammatory Mechanisms Of Hormone Allergy

The inflammatory mechanisms of allergic reactions to hormone allergens, which are intrinsic to the body, are the same as the mechanisms of allergic reactions to external allergens. The difference is in the magnitude and manifestation of discomforts. As the body is not constantly being exposed to external allergens, the discomforts in response to allergen exposure are not continuous. Hormones being within the body can induce allergies that result in chronic ailments, although the expression of symptoms can vary with the day of the menstrual cycle in females depending on the hormone load.

How To Treat Estrogen Levels

If you think that your estrogen levels are off, then there are a number of ways to test them. The common way is a blood test. This may be helpful if you are testing progesterone levels in the follicular phase . If your cycles are irregular, the best time to test this is right after any form of a period that you might have. Measuring estrogen levels are not as sensitive as progesterone levels during a womens cycle and they can be measured any time in men.

Similar to progesterone, you can also dobasal body temperatures to help assess your estrogen levels. You can chart the temperatures over time, and the data that you get will tell you what your hormones are doing daily. When estrogen levels are high in the follicular phase, your temperatures should be on the low side. Temperatures often rise when estrogen levels are low

If your estrogen levels are too high, or you have an imbalance of estrogen and progesterone, then there are several ways you can treat this. Usually you will want to make sure that you increase progesterone levels if that is low. That can counteract the estrogenic effects on the immune system. Some other supplemental approaches that can help are things like indole-3-carbinol and DIM, which help with the breakdown of estrogen. Liver support is also super important as it helps with hormone breakdown in the body.

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How Do I Find Out If I Have An Autoimmune Disease

Getting a diagnosis can be a long and stressful process. Although each autoimmune disease is unique, many share some of the same symptoms. And many symptoms of autoimmune diseases are the same for other types of health problems too. This makes it hard for doctors to find out if you really have an autoimmune disease, and which one it might be. But if you are having symptoms that bother you, it’s important to find the cause. Don’t give up if you’re not getting any answers. You can take these steps to help find out the cause of your symptoms:

  • Write down a complete family health history that includes extended family and share it with your doctor.
  • Record any symptoms you have, even if they seem unrelated, and share it with your doctor.
  • See a specialist who has experience dealing with your most major symptom. For instance, if you have symptoms of inflammatory bowel disease, start with a gastroenterologist. Ask your regular doctor, friends, and others for suggestions.
  • Get a second, third, or fourth opinion if need be. If your doctor doesn’t take your symptoms seriously or tells you they are stress-related or in your head, see another doctor.

Estrogen And Microrna In Post

External Causes of Hormonal Imbalances · Mango Clinic

Estrogen upregulates miR-18a, miR-148a, miR-223, miR-451, miR-486, and miR-708, and downregulates SLE-linked miR-125, miR-145, and miR-146a. Microarray analysis showed that estrogen differentially regulates miRs in murine splenocytes in vivo. Treatment of mice with E decreases miR-146a and increases miR-223 which suppresses lipopolysaccharide -induced IFN- and nitric oxide in splenic lymphocytes . miRs can also influence ER expression and modulate ER activity in disease . Estrogen activates STAT1-dependent transcriptional activation of TLR8 expression to promote inflammatory signaling via miR-21 in extracellular vesicles . A major role of estrogen is in bone remodeling and a protective role of estrogen is to suppress osteoclast mediated bone resorption. A novel mechanism by which estrogen preserves bone mass in bone marrow mesenchymal stem cells s is to induce apoptosis of osteoclasts to protect from bone loss. Estrogen inhibits miR-181, which blocks FasL. Therefore estrogen promotes FasL protein expression by miR mediated posttranscriptional regulation in BMMSCs to maintain bone remodeling balance. In menopause, low estrogen levels, increased miR-181 and reduced FasL can promote survival of osteoclasts and increase bone loss .

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The Role Of Infection And Disease

On a basic level, autoimmune disease occurs because the bodys natural defenses the immune system attack the bodys own healthy tissue. Researchers have several ideas about why this happens.

When the body senses danger from a virus or infection, the immune system kicks into gear and attacks it. This is called an immune response. Sometimes, healthy cells and tissues are caught up in this response, resulting in autoimmune disease.

Many scientists believe this is what causes rheumatoid arthritis, a type of autoimmune disease that attacks the joints. Its also common that after having strep throat, people develop psoriasis, an autoimmune condition that causes patches of thick, scaly skin.

Other types of autoimmune disease may come from the body trying to fight specifically against cancer cells. Orbai points to scleroderma, a disease that causes thickening of the skin and connective tissues. The thought is that when the immune system gets rid of the cancer, there is a leftover inflammatory response because of that fight, she says. Johns Hopkins researchers studied patients who developed both scleroderma and cancer to try to clarify this relationship.

Hormone Allergy And Hormone Allergens

It may not be a familiar idea that a physiological body constituent can be an allergen. There are other examples of type I hypersensitivity induced by an endogenous protein or chemical. IgE responses to endogenous proteins can be triggered by any condition that causes necrosis, because intracellular proteins are released that do not otherwise have access to IgE or any other surface-bound antigen receptor. For example,Polacek et al. have reported a characteristic finding, that there was a rapid and dramatic increase of IgE in the serum of all patients with severe burn injury. Some of them showed up to 20-fold increase. IgE was also found in considerable amounts in blister fluid and pleural effusions. In some patients, raised IgE values were the only indicator of an immediate allergic state. Thus simple trauma to the skin is not a sufficient explanation for the elevated serum IgE levels in atopic dermatitis and generalized neurodermatitis. Some other mechanisms might be involved.

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Get Restorative Sleep To Balance Hormones:

Make it a priority to get eight or more hours of high-quality sleep each night to balance your hormones and keep extra weight off. Accumulating evidence indicates that chronic sleep deprivationdefined as less than seven or eight hours a nightcauses hormonal imbalance including elevated insulin levels, increased nighttime cortisol, increased levels of the hormones that increase your hunger and appetite .

If you are struggling with poor sleep, there are many things you can do to improve it. Read this article to discover the main factors causing you to sleep poorly and strategies you can apply today to improve your sleep quality.

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How To Reverse Gut Health Problems With Autoimmune Disease And Hormonal Imbalances

Reviewed and edited by a celiac disease expert.Caption:

Celiac.com 05/16/2011 – Nearly 75% of the 24 million Americans suffering from autoimmune disease are women, according to the American Autoimmune Related Diseases Association . Women appear to mount larger inflammatory responses than men when their immune systems are triggered, thereby increasing their risk of autoimmunity. The fact that sex hormones are involved is indicated by the fact that many autoimmune diseases fluctuate with hormonal changes such as those that occur during pregnancy, during the menstrual cycle, or when using oral contraceptives. A history of pregnancy also appears to increase the risk for autoimmune disease.

Celiac.com Sponsor :They based their study on the known data that DHEA not only declines with aging but is reduced in Sjogrens, an autoimmune disease. The study was populated by 23 post-menopausal women with primary Sjogrens syndrome and subnormal levels of DHEA. The investigation was a controlled, double blind crossover study, conducted over a 9 month period, where DHEA was assessed by sophisticated laboratory measurements and typical symptoms of Sjogrens such as dry mouth and eyes and salivary flow rates were similarly assessed.

Results revealed a strong correlation between low DHEA and Sjogrens symptoms. DHEA and its sex hormone metabolites were found to increase with DHEA supplementation but not with the placebo. Symptoms such as dry eyes were seen to improve as estrogen levels

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Oral Contraceptives And Hormone Therapy

For many years, oral contraceptives were incriminated as a cause of heightened lupus activity. These observations might relate to the total amounts of ethinyl estradiol in early preparations. Further research has indicated, however, that oral contraceptives can be used safely in patients with lupus.9 The same was true of hormonal replacement therapy in postmenopausal women with the disease. However, a secondary manifestation of procoagulant activity, antiphospholipid syndrome, may coexist with systemic lupus in certain patients and is a denite contraindication to any estrogen use, preor postmenopausal.

New Findings Link Estrogen And T Cell Immune Response To Autoimmune Inflammation

Date:
University of Turku
Summary:
Women are more prone to the development of autoimmune diseases. The female hormone estrogen is likely to affect the immune system. A team of scientists reported new findings related to the involvement of estrogen hormone receptor in autoimmune diseases.

Women are more prone to the development of autoimmune diseases. The female hormone estrogen is likely to affect the immune system. A team of scientists from Turku Center for Biotechnology and University of Georgia reported new findings related to the involvement of estrogen hormone receptor in autoimmune diseases.

The incidence of autoimmune diseases such as MS, RA, and SLE is higher in women than in men. The estrogen hormone secreted in women may contribute to the pathogenesis of these diseases.

A research team led by Docent Zhi Chen from Turku Center for Biotechnology of the University of Turku has collaborated with researchers from the University of Georgia, United States to address the long-standing issue of hormonal effect on autoimmune diseases.

Estrogen hormone shows its action on cells mostly through estrogen receptor alpha . Researchers from Turku generated mice with ER protein specifically deleted in T cells.

“The eureka moment of our research is that in a mouse model of human inflammatory bowel disease, transfer of naive T helper cells from ER deficient mice did not succumb to colitis, unlike transfer from their counterparts,” Docent Zhi Chen tells.

Story Source:

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How Do Hormones Affect Ra

Medical experts have been investigating links between RA and hormone levels. For women, maintaining normal levels of the reproductive hormones estrogen and progesterone appear to have a protective effect against RA.

Research on a small group of middle-aged women with RA found that they tended to report fewer joint symptoms during the postovulatory stage of their menstrual cycles and during pregnancy. These events cause the levels of estrogen and progesterone to increase.

Women with RA also reported that their symptoms worsened after childbirth and during the second week of their menstrual cycles when reproductive hormone levels were lowest.

The levels of reproductive hormones in womens bodies decrease with age. Women who are approaching or who have gone through menopause have decreased levels of these hormones. Some researchers believe thats why this group of women experience RA more than any other segment of the population. This is also why some doctors recommend women experiencing menopause begin hormone replacement therapy .

Research suggests that HRT, which involves using a combination of progesterone and oestrogen, can decrease the overall activity of a womans RA.

However, it may increase the intensity of disease flare-ups when they do occur. There are also some possible side effects that include:

  • fluid retention
  • drugs to slow down the progression of RA
  • biologic agents to stop certain parts of the immune system from triggering inflammation

Tips On How To Lower Inflammation And Balance Hormones

Signs Of Common Hormonal Imbalances In Men
  • Get tested if youre between the ages of 35-45 to know your baseline hormones. This will help you see where your imbalance lies in order for you to help your body restore whats dipping or missing.
  • Add an adaptogenic herb like Relora or Ashwagandha to help the body adapt to stress. Adaptogens improve the entire bodys resistance to stress and create balance and harmony in the body, thereby reducing inflammation and balancing hormones
  • Eat your vegetables! Vegetables contain hundreds to thousands of phytonutrients that have a hormone-balancing effect in the body. Vegetables also contain fiber that binds itself to old estrogens, thereby clearing them out of the system, leading to lower inflammation and better hormonal balance.
  • Remove inflammatory foods from your diet, such as processed dairy, gluten, alcohol, sugar, processed snacks, omega-6 oils, and soy. These can incite inflammation and create hormonal imbalance. Food insensitivities and inflammatory food can lead to leaky gut, inflammation, and systemic imbalance, which in turn can put hormones in flux.
  • Eat healthy fats like: coconut oil, avocados, olive oil, and grapeseed oil. Steer clear of vegetable oils, peanut oil, canola oil, soybean oil, cottonseed oil, sunflower oil, margarine, shortening or spreads
  • Watch for endocrine disruptors or hormone disruptors like plastics, air fresheners, dishwashing soap, laundry detergent, cleansers and cleaners, cosmetics, deodorants, toothpaste, and lotions.
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    What Are Autoimmune Diseases

    An autoimmune disease occurs when your immune system begins attacking your body instead of foreign contagions, such as viruses and bacteria.

    The immune system works by marking foreign proteins and then destroying them. However, for those with an autoimmune disease, the immune system mistakenly marks proteins that are a part of you. Then, when the immune system sets out to destroy any marked proteins, it ends up attacking itself.

    Sex hormones appear to play a role in autoimmune diseases since these diseases typically fluctuate with hormonal changes. For example, some instances that cause autoimmune diseases to flare up include the menstrual cycle, pregnancy, or using oral contraceptives. All of these instances result in dramatic changes in female sex hormone levels.

    Signs And Symptoms Of A Hormonal Imbalance

    Your hormones play an integral role in your overall health. As a result, theres a broad range of signs and symptoms that could signal a hormonal imbalance. Your signs or symptoms will depend on which hormones or glands are not working properly.

    Common hormonal conditions affecting people of all genders could cause any of the following signs or symptoms:

    • purple or pink stretch marks

    Keep in mind that these symptoms are nonspecific. Having one or a few of them doesnt necessarily mean that you have a hormonal imbalance.

    Some of these symptoms may also reflect other chronic conditions. So, if you find yourself dealing with any notable changes in your body or energy levels, its a good idea to talk with your doctor.

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    Why Nearly 80 Percent Of Autoimmune Sufferers Are Female

    The effects of sex hormones, X chromosomes and different gut microbes may be parts of the answer

    Melinda Wenner Moyer, a contributing editor at Scientific American, is author of How to Raise Kids Who Arent Assholes: Science-Based Strategies for Better ParentingFrom Tots to Teens .

    Melinda Wenner Moyer, a contributing editor at Scientific American, is author of How to Raise Kids Who Arent Assholes: Science-Based Strategies for Better ParentingFrom Tots to Teens .

    Melanie Sees first bout of odd symptoms began in 2005. Suddenly she started sweating a lot. She rapidly lost 10 pounds. She got dizzy walking from the bedroom to the couch. She started lactating even though she was not nursing a baby. After a slew of laboratory tests, See, then 45, was diagnosed with Graves disease, an autoimmune disorder that makes thyroid hormones surge.

    After many tests, See was diagnosed with yet a third autoimmune illness: mixed connective tissue disease, a rare ailment that shares some features of lupus.

    Women account for an estimatedand astonishing78 percent of people who have these disorders, which include Sees afflictions, as well as lupus, multiple sclerosis, rheumatoid arthritis, and other illnesses in which the bodys immune system mistakenly attacks its own cells and tissues. Autoimmune diseases are now the fifth-leading cause of death in women younger than 65.

    How Do You Fix Hormonal Imbalance

    Hormone Imbalance: How to Start Fixing It with Maggie Yu MD IFMCP

    Many health conditions that involve hormonal imbalances, such as diabetes and thyroid disease, require medical treatment.

    Many nutritional supplements in stores claim to treat different hormonal imbalances, but few of them have been scientifically proven to have a beneficial effect. Its important to always talk to your healthcare provider first about taking supplements.

    Aside from medical treatment, your provider may recommend certain lifestyle changes to help manage a hormonal imbalance, such as managing your stress levels and getting routine exercise.

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    What Are Some Things I Can Do To Feel Better

    If you are living with an autoimmune disease, there are things you can do each day to feel better:

    You have some power to lessen your pain! Try using imagery for 15 minutes, two or three times each day.

  • Put on your favorite calming music.
  • Lie back on your favorite chair or sofa. Or if you are at work, sit back and relax in your chair.
  • Close your eyes.
  • Imagine your pain or discomfort.
  • Imagine something that confronts this pain and watch it “destroy” the pain.
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