Saturday, March 2, 2024

Long Term Effects Of Mtf Hormones

Newsnew Report Details High Heart Disease Risk In South Asians In Us

Feminizing Hormone Therapy at Seattle Childrens

He stressed that hormone therapy is lifesaving for many transgender people, who often struggle with depression or even contemplate suicide if denied it.

The risks here are not different from many other medications and therapies that are used, he said. There need to be more studies focused on trans-identified people so we can learn risks specific to them and provide better care.

When Can People Take It

The age at which people can access gender affirming hormone therapy varies globally.

For example, in Europe, many countries allow people aged 1418 to access it. However, in some countries, such as the Netherlands, people can access it from the age of 12 years with parental consent.

In some other European countries, access depends on the maturity of the person who would like to receive the therapy.

In the U.S., most people can access estrogen hormone therapy at the age of 18 years, when they are capable of consent. At 17 years old, a person may have access, but they will require a parent or guardian to accompany them to appointments. At the age of 16 years or younger, additional paperwork is necessary to access such therapy.

People using estrogen and anti-androgens as part of their hormone treatment may notice:

  • drier and thinner skin with smaller pores
  • changes in the odors of sweat and urine
  • a reduction in sweat production
  • the development of breast buds beneath the nipples that will develop into breasts as treatment progresses
  • a more feminine facial appearance
  • an increase in fat around the hips and thighs
  • a loss of muscle mass in the arms and legs
  • a reduction in strength

Research also indicates that cross-sex hormone treatment changes the structure of the brain to bring trans people closer to their identified gender.

These changes could potentially affect a persons verbal and spatial abilities and the way they interact with others.

Typical Changes From Estrogen

See Average timeline Effect of Estrogen

13 months after starting estrogen softening of the skin

Breast and nipple growth starts early but is usually gradual it cantake two years or more for breasts to reach their maximum size. As innon-trans women, there is great variation in how large breasts grow fromestrogen. In many MTFs breasts do not grow beyond an A or B cup. If youare not happy with the size of your breasts after 1824 months on estrogen,you can consider surgical augmentation . The implants will look most natural if you wait to get as muchgrowth as you can from hormones.

Most of the effects of hormones happen in the first two years. Duringthis time, the doctor who prescribes your hormones will want to see youone month after starting or changing your dose, then 34 times in thenext year, then every six months. At appointments in the first two years,your doctor will likely:

look at your facial/body hair and ask how fast your hair grows backafter you remove it measure your breasts, hips, and testicles, and examine yourbreast/nipple development ask about changes to your sex drive, erections, or other sexualchanges

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Feminizing Hormone Replacement Therapy Medication And Timing

While your healthcare provider will help you develop an individualized treatment plan, feminizing hormone therapy often begins by taking 100 to 200 milligrams daily of a diuretic called spironolactone to begin blocking male hormone receptors and suppress testosterone production. Some individuals begin taking estrogen immediately, in tandem with spironolactone, to further reduce testosterone production and develop more feminine characteristics. In other cases, estrogen is introduced after several weeks of spironolactone use. Your doctor will recommend the best plan for your needs.

There are various methods for administering estrogen, including orally, by injection, or as a cream, gel, spray, or patch. Commonly used forms of estrogen during a male-to-female transition include:

Type Of Pharmacotherapy Received And Dosage

Testosterone therapy for transgender men

Transgender women before and after gonadectomy received different forms of estrogens and testosterone suppressors meanwhile, transgender men received mainly testosterone therapy before and after surgery .

Different dosages and various methods of administration were observed. The differences in pharmacologic treatment were the result of patient-centered approaches more than those that were guided by the specific pharmacological protocol from the treatment center .

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Two Main Bone Turnover Markers

Following the recommendations by the International Osteoporosis Foundation and the International Federation of Clinical Chemistry for the quantification of the bone turnover , the N-terminal pro-peptide of type I procollagen and C-telopeptide of type I collagen were recorded . Respectively, PINP measures bone formation and CTX-I measures bone resorption .

This review showed that hormone therapy induced an increase in the PINP values in M to F patients and an increase of PINP in F to M patients . Meanwhile, the CTX values in M to F and F to M were inconsistent .

During transgender hormone therapy, the goal is similar to the goal of the antiresorptive treatmentto lower the PINP by at least 10 ng/mL and < 35 ng/mL during bone resorption. Meanwhile, during bone formation, the goal is to raise the PINP by at least 10 ng/mL to achieve a level of > 69 ng/mL .

Therefore, it seems that the long-term administered pharmacotherapy for M to F and F to M transgender patients can produce a slight increase in the bone formation rates evaluated with the PINP . It should also be considered that these PINP values can change over time, induced by factors such as age, metabolism changes, and non-compliant treatment interruption .

Environmental Effects Of The Pill: 79% Of Male Smallmouth Bass In The Potomac Growing Eggs

A later Washington Post article described how scientists said the cause is probably some pollutant created by humans perhaps a farm chemical, or treated sewage, which can contain human hormones or residue from birth-control pills. The later Post article reported that scientists think the problem is caused by a mixture of hormone and hormone-mimicking pollutants and have found negative effects on female fish as well.11

Iain Murray, author of The Really Inconvenient Truths, wrote on National Review Online, By any standard typically used by environmentalists, the pill is a pollutant. It does the same thing, just worse, as other chemicals they call pollution.

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Should I Take A Break From My Birth Control Pills Just To Be Safe

Sure, why not? Experts say theres no need, but if it makes you feel better to experience one or two natural cycles, after being on birth control pills for years, then go for it. But just remember, if you arent taking birth control pills, youll need to use another form of contraception if you want to avoid pregnancy.

Risks Of Other Forms Of Birth Control

Deciding to Stop Transitioning After 18 Months of Hormone Therapy

Birth control pills and other forms of birth control are generally considered safe to use long-term but do carry risks that everyone taking them should know.

  • Increased risk of blood clots, stroke, and heart attack:People who take birth control pills are at a higher risk of developing blood clots or having a stroke or heart attack. Pills with higher doses of estrogen are considered to raise the risk even more.
  • Increased risk of some cancers:Some studies have shown that people taking birth control are almost twice as likely to develop breast cancer as people who do not take it. The risk of developing cervical cancer also appears to be higher among people taking birth control pills.
  • High blood pressure:Increased blood pressure can occur in people taking birth control pills. Although the increase is typically mild, there have been rare cases where a persons blood pressure rose to dangerously high levels while they were taking birth control.
  • Increased risk of gallbladder disease: Research has shown that taking birth control pills for a long time may increase a persons risk of developing gallbladder disease by 36%. Taking birth control pills may also increase a persons risk of developing gallstones.
  • Lowered libido: Some research has suggested that people taking birth control may have a lowered libido, though the results of several studies have been conflicting. More research is needed to determine how long-term birth control use affects a persons sex drive.

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Enhancing Healthcare Team Outcomes

Oral contraceptive pills provide patients with the option to prevent pregnancy. If the patient has medical conditions that put them at increased risk for taking combined OC or progestin OC, the prescriber should inform patients of many alternatives to prevent pregnancy. OCâs are a choice made by the patient and her clinician after adequate counseling of risks and benefits. There are significant non-contraceptive uses of hormonal contraceptives, and these should be considered when counseling the patient about her options. Many OC formulations can provide menstrual regularity, treating both menorrhagia and dysmenorrhea. They can even be utilized to induce amenorrhea for lifestyle considerations.

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Main Body Changes Induced By Mtf Hrt


We do not provide HRT at the 2pass Clinic. Please contact your doctor or specialist for more information.

The impact of Hormone Replacement Therapy on the Male-to-Female body varies greatly from person to person, and it is therefore wise to stay realistic. But there are six significant effects that are generally quite common!

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Bone Metabolism Markers And Their Potential Effect On Implant Therapy

Calcium and phosphates are responsible for calcium homeostasis and participate in the acidbase balance and also facilitate the release of growth factors embedded in bone . The action of the osteoclasts on the calcified bone matrix facilitates its dissolution and releases calcium ions into the blood to form blood calcium . In a parallel action, the calcium contained in the blood flow can be deposited onto the bone to form bone calcium, mediated by the osteoblasts. These phenomena are regulated by enzymes and hormones .

In the presence of metabolic imbalances produced by the cross-sex pharmacologic therapies, the blood calcium balance system can be altered, thereby playing an important role as an ethiological factor for pharmacologically induced osteoporosis .

These pharmacologic therapies can also alter the phosphorus/calcium ratio. The reduction of phosphorus can alter the calcium absorption, while increased phosphorus concentrations can increase the oxidative stress as well as the hormonal balance between phosphates, calcium, and vitamin D. This might be conducive to adverse effects on mineral metabolism and increased bone loss .

What To Know About Transgender Hormone Therapy Side Effects

Just for anyone that

Alto Pharmacy

For many transgender men and women, hormone replacement therapy is an important component of their transitioning process, allowing them to develop physical traits aligned with their gender identity. Taking this step to feel more comfortable in your body is a big decision, and there are many factors to consider as you determine if gender-affirming hormone replacement therapy is right for you.

Below is an overview of hormone replacement therapy medications and side effects to help you learn more about the process.

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Mtf Hormones: A Guide To Estrogen And Gender

Not all trans women experience gender dysphoria. But for those who do, that disconnect between ones assign sex at birth and ones gender identity can be distressing, leading to depression, anxiety, and poor self-esteem.

One way to alleviate that distress is to undergo hormone therapy , which involves the use of MTF hormones like estrogen and progesterone to encourage physical changes in ones body. These changes will have a feminizing effect on the body, bringing patients one step closer to feeling happier and more comfortable in their own skin.

There is no one-size-fits-all solution to gender dysphoria. But if you think that hormones could help you, read on to discover how hormone therapy works, what MTF HRT body changes look and feel like, and how you can prepare for the process.

Doctors Debate Whether Trans Teens Need Therapy Before Hormones

Clinicians are divided over new guidelines that say teens should undergo mental health screenings before receiving hormones or gender surgeries.

Laura Edwards-Leeper, a child clinical psychologist in Beaverton, Ore., who works with transgender adolescents, said they absolutely have to be treated differently than adults.Credit…Kristina Barker for The New York Times

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An upsurge in teenagers requesting hormones or surgeries to better align their bodies with their gender identities has ignited a debate among doctors over when to provide these treatments.

An international group of experts focused on transgender health last month released a draft of new guidelines, the gold standard of the field that informs what insurers will reimburse for care.

Many doctors and activists praised the 350-page document, which was updated for the first time in nearly a decade, for including transgender people in its drafting and for removing language requiring adults to have psychological assessments before getting access to hormone therapy.

They absolutely have to be treated differently, said Laura Edwards-Leeper, a child clinical psychologist in Beaverton, Ore., who works with transgender adolescents.

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Tips For Parents To Help Their Struggling Teens

Are you concerned for your teen?If you worry that your teen might be experiencing depression or suicidal thoughts, there are a few things you can do to help. Dr. Christine Moutier, the chief medical officer of the American Foundation for Suicide Prevention, suggests these steps:

Look for changes.Notice shifts in sleeping and eating habits in your teen, as well as any issues he or she might be having at school, such as slipping grades. Watch for angry outbursts, mood swings and a loss of interest in activities they used to love. Stay attuned to their social media posts as well.

Keep the lines of communication open.If you notice something unusual, start a conversation. But your child might not want to talk. In that case, offer him or her help in finding a trusted person to share their struggles with instead.

Seek out professional support.A child who expresses suicidal thoughts may benefit from a mental health evaluation and treatment. You can start by speaking with your childs pediatrician or a mental health professional.

In an emergency:If you have immediate concern for your childs safety, do not leave him or her alone. Call a suicide prevention lifeline. Lock up any potentially lethal objects. Children who are actively trying to harm themselves should be taken to the closest emergency room.

Some clinicians worry that public disagreement over the best way to care for transgender adolescents will add fuel to this simmering political movement.

Practical Guidelines For Transgender Hormone Treatment

Gender Health: Gender Affirming Hormone Therapy | UCLA Health

Adapted from: Gardner, Ivy and Safer, Joshua D. 2013 Progress on the road to better medical care for transgender patients. Current Opinion in Endocrinology, Diabetes and Obesity 20: 553-558.


  • In order to improve transgender individuals access to health care, the approach to transgender medicine needs to be generalized and accessible to physicians in multiple specialties.
  • A practical target for hormone therapy for transgender men is to increase testosterone levels to the normal male physiological range by administering testosterone.
  • A practical target for hormone therapy for transgender women is to decrease testosterone levels to the normal female range without supra- physiological levels of estradiol by administering an antiandrogen and estrogen.
  • Transgender adolescents usually have stable gender identities and can be given GnRH analogs to suppress puberty until they can proceed with hormone therapy as early as age 16.

Hormone regimes for transgender men

1. Oral

2. Parenterally

  • Testosterone enanthate or cypionate 50200mg/week or 100200mg/2 weeks
  • Testosterone undecanoate 1000 mg/12 weeks

3. Transdermal

  • Testosterone 1% gel 2.5 10 g/day
  • Testosterone patch 2.5 7.5 mg/day

i.m., intramuscular.*Not available in the USA.

Monitoring for transgender men on hormone therapy:

  • Monitor for virilizing and adverse effects every 3 months for first year and then every 6 12 months.
  • Monitor hematocrit and lipid profile before starting hormones and at follow-up visits.
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    At What Point In My Gender Transition Can I Start Feminizing Hormone Therapy

    The timing is up to you and your healthcare provider. Some people affirm their new gender identity first by changing their names and dressing differently. But this isnt a requirement.

    Adolescents may wish to consider starting feminizing hormone therapy at age 16. Starting at a young age makes it possible to:

    • Block the effects of puberty for their assigned gender.
    • Proceed with puberty in a manner consistent with their authentic gender identity.

    How Do I Prepare For Feminizing Hormone Therapy

    There are many steps to help you prepare, including:

    • Patient education to explain how treatment works and what to expect. This includes reviewing risks and benefits.
    • Medical history to check for estrogen-dependent conditions, like certain breast cancers and endometriosis.
    • Physical exam to ensure you are healthy enough to start feminizing hormone therapy.
    • Lab tests, including a blood panel, urinalysis and liver function test.
    • Mental health evaluation to make a gender dysphoria diagnosis. It also confirms your understanding of therapy and ability to agree to it.

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    Hrt Timeline And Effects: Hormone Replacement Therapy Info

    by GenderGP | Jul 13, 2021 | Medical

    HRT has a timeline. The results dont happen instantly. If youre considering hormone replacement therapy, or just starting them for the first time, its important to know what effects to expect and when to expect them. Bear in mind that everyone is different and that not everyone will have the same journey. These timescales are rough estimates to give you a sense of how the transition might progress. Here, we explore the FTM testosterone changes timeline and MTF HRT effect timeline.

    *Please note: We use terminology like AMAB , MtF , and trans-feminine interchangeably for understanding across all age groups, cultures, genders, and identities. For more information. check out our glossary of terms. youll see us use it here with the likes of FTM testosterone changes timeline and MTF HRT effect timeline.

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