What’s The Right Time To Eat
- When you eat matters too. Youre setting your hormonal balance for the entire day so be sure to eat within an hour of waking and stop about three hours before bedtime. This pattern will not only keep your energy and moods balanced, but it will also help you build more growth hormone a fountain-of-youth hormone for sure.
- Focus on protein and healthy fats in the morning and carbohydrates in the evening. We tend to be more insulin-resistant in the morning so if we eat carbohydrates at that time, like fruits and grains, we will store it as fat more quickly.
Synthetic Combination Therapy And The Rationale For Its Use
13a.Do genetic variants in thyroid hormone pathway genes affect the serum or tissue levels of thyroid hormones in healthy euthyroid individuals or hypothyroid patients taking replacement therapy?
Summary statement
Specific polymorphisms in the deiodinases are consistently associated with very small changes in serum thyroid hormone levels. Insufficient data exist to draw any conclusion about the clinically relevant effects of deiodinase or transporter polymorphisms on tissue thyroid hormone levels.
Mechanistic background
Twin and family studies have shown that between 26% and 65% of the variation in serum thyroid function tests is due to genetic factors . Genetic variants can be divided into two broad classes, based on their frequency and their functional effects on the target gene. Polymorphisms are common genetic variants that occur frequently in the population and generally have only very modest effects on gene function. In contrast, mutations are rare genetic variants with major effects on gene function leading to monogenic disorders such as RTH, RTH , or the Allan-Herndon-Dudley syndrome due to mutations in the TH transporter MCT8 . While no patients have been identified with functionally important deiodinase mutations, seven patients with mutations in SECISBP2, a gene critical for the synthesis of selenocysteine containing proteins including the deiodinases, have been identified. Affected individuals have a mild phenotype but do exhibit decreased serum T3 levels .
Approach Utilized In Conducting This Review
Our task force was commissioned and approved by officers of the ATA. We formed in the summer of 2011 and our composition included members with particular expertise in mechanistic and translational science , members with particular expertise in clinical thyroidology , a member with a background in pediatric endocrinology, a member with expertise in design and evaluation of health research, and a bioethicist. As of October 2011, we were redirected and specifically asked to develop clinical practice guidelines. Our task force met face to face in October 2011, June 2012, September 2012, June 2013, October 2013, and June 2014 with seven interim discussions using conference calls. A spring meeting of the ATA that was open to all potential stakeholders was held on April 25 and 26, 2013, to highlight and promote broad discussion regarding relevant and topical issues . Information needs identified by stakeholders at this meeting were incorporated in task force group decisions in considering topics for review.
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How To Balance Your Hormones With Food
- Yes, what we eat does matter in fact its essential to feeling fabulous. Thats because its the information we give our body to functionor dysfunction. So choose function for hormone balance, and eat good quality proteins, fats and vegetables with a dollop of starchy carbohydrate at every meal three times a day.
- Be sure to eat plenty of vegetables every day to help build muscle and bone and have enough minerals and fiber to run all of your bodys processes.
Thyroid Hormone Analogs And Resistance To Thyroid Hormone
24a.What are the clinical and biochemical goals for treatment of patients who have genetic syndromes of resistance to thyroid hormone?
Recommendation
The therapeutic goals of the treatment of patients with genetic syndromes of resistance to thyroid hormone are to improve the symptoms caused by excessive TR signaling, while minimizing the symptoms caused by deficient TR signaling.
Weak recommendation. Low-quality evidence.
24b.What is the role of thyroid hormone analogs in treating patients who have genetic syndromes of resistance to thyroid hormone?
Recommendation
Although preliminary data from small case series suggest that the use of TRIAC in patients with genetic syndromes of resistance to thyroid hormone may be promising, more clinical research is needed before the use of thyroid hormone analogs can be recommended for this indication.
Weak recommendation. Low-quality evidence.
Mechanistic background
Hypothetically, a TH analog with a preference for TR might be useful in treatment of RTH patients, since it would normalize TSH and lower TH production, while normalizing TH signaling directly in TR dominant tissues. Treatment with TRIAC, which has a higher affinity for TR than for TR has been used in a number of patients based on this rationale.
Discussion of the clinical literature
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Role Of Srcs In Other Rth Models
Inability to recruit co-activators by mutant THRB is thought to play a role in the development of RTH. In ThrbPV mutant mice, a model of RTH with a knock-in mutation in the Thrb locus that completely abolishes T3 binding to THRB , lack of Src1 leads to a worsening of the HPT axis dysregulation and growth abnormalities in ThrbPV/+ mice but not in ThrbPV/PV mice. In TrbPV/PV animals, Src1 deficiency intensified the pathological progression of thyroid follicular cells to papillary hyperplasia. Lack of Src1 did not affect serum cholesterol levels in either ThrbPV/+ or ThrbPV/PV mice, but led to dysregulated expression of several T3 target genes in the pituitary and liver .
Choice Of Levothyroxine Product
2a.Is there a clinical rationale for prescribing brand-name levothyroxine preparations in preference to generic levothyroxine?
Recommendation
Prescription of brand name levothyroxine, or alternatively maintenance of the same generic preparation , is advised. Switches between levothyroxine products could potentially result in variations in the administered dose and should generally be avoided for that reason .
Weak recommendation. Low-quality evidence
Strong recommendation. Low-quality evidence
Strong recommendation. Moderate-quality evidence
Discussion of the clinical literature
Blakesley et al. , in a study funded by Abbott Laboratories, studied the FDA-recommended pharmacokinetic process of comparing LT4 products. Even when correction was made for endogenous serum T4 levels in healthy individuals, enabling the detection of differences in the administered dose of 25% and 33%, they could not distinguish acute LT4 doses that differed by 12.5%, leaving open the precise sensitivity of this method to exclude clinically meaningful differences in bioavailability between products considered equivalent.
2b.Are there situations in which therapy with levothyroxine dissolved in glycerin and supplied in gelatin capsules may have advantages over standard levothyroxine?
Discussion of the clinical literature
There is the theoretical possibility that gel capsules or liquid LT4 would be useful in patients with allergies to any of the excipients in solid LT4 tablets.
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Liothyronine Monotherapy In Euthyroid Patients
15a.Is there a role for the use of liothyronine to treat biochemically euthyroid patients with depression?
Recommendation
Although some uncontrolled and nonrandomized data exist concerning successful use of liothyronine in euthyroid patients with depression, larger, prospective randomized placebo-controlled studies are needed to more completely define the potential role of liothyronine in this condition, balancing the risks and benefits of therapy to measurable clinical outcomes.
Weak recommendation. Low-quality evidence.
Discussion of the clinical literature
Despite advances in our understanding of T3-mediated genomic as well as nongenomic actions at the cellular level , the role for LT3 in optimizing TH replacement therapy has not been clearly elucidated . With increased recognition of the biologic importance of T3 at the cellular level, and the concerns that biochemical euthyroidism may not equate to tissue euthyroidism, there has been an increasing dialogue regarding whether LT3 therapy may be effective in reducing symptoms seen in euthyroid patients as well as in patients with depression, obesity, and cardiovascular disease.
15b.Is there a role for the use of liothyronine to treat biochemically euthyroid patients with obesity?
Discussion of the clinical literature
Warning About New ‘hormone Reset Diet’
BOSTON – There’s a newcomer to the diet scene. It’s called the Hormone Reset Diet and it promises to help women lose weight, but Dr. Mallika Marshall says before you sign on, there are some things you should know.
This new method was conceived by a doctor, a gynecologist in California. She claims women can lose 15 pounds in 21 days if they follow seven dietary guidelines, each designed to address a specific hormonal imbalance.
For example, for estrogen, go meatless and eliminate alcohol. Get rid of fruit to reset the hunger hormone, leptin. Toss out grains to reset your thyroid, and remove dairy to address your growth hormone levels.
You’re supposed to make one of seven dietary changes every three days.
But Boston University registered dietician and nutrition professor, Joan Salge Blake, says with this hormone reset diet, there are some real red flags.
“There’s no literature to suggest that you can by cutting certain foods out of your diet reset your hormones,” says Salge Blake. “Nor do you have to reset your hormones for you to lose weight. Another gut check? Be careful when you see weight loss plans that try to eliminate whole food groups. That’s usually a flag saying why does a whole food group need to be eliminated when you’re trying to lose weight?”
Salge Blake adds that there is really no science to back up this diet, and even though you will probably lose weight, you’re unlikely to be able to keep the weight off.
First published on April 13, 2015 / 5:21 PM
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Smrt Receptor Interacting Domain Mutant Mice
SmrtmRID mouse model bears mutations in two Smrt RIDs , which abolish its interactions with RAR, TR, and PPAR isoforms . SmrtmRID mice are born at expected ratios, but have slightly reduced viability on a mixed C57BL/6-Sv129 genetic background. Adult animals display a number of metabolic disturbances: significantly increased adiposity with reduced body weight, decreased EE, and RER, increased basal hepatic glucose production, and diminished insulin-stimulated glucose disposal leading to elevated fasting glucose and glucose intolerance. MEFs isolated from SmrtmRID mice demonstrate increased PPARG signaling and adipogenic potential suggesting that SMRT, by repressing signaling by PPARG and potentially other NRs, plays an important role in determining the adipogenic set point. Hypothyroid SmrtmRID mice demonstrate significant derepression of some TH target genes in the liver and improvement of hypothyroidism-induced hypercholesterolemia, indicating that SMRT plays a role in repression of positive TR targets in the absence of hormone. This is contrary to what was seen in the liver-specific Smrt knockout , and whether the differences are due to the whole-body vs liver-specific deletion or the ability of mutant SmrtmRID to still bind HDAC3 and other components of the repression machinery remains to be clarified.
The Wonders Of Hormone Reset Programs With Robin Nielsen
May 3, 2022
On this weeks episode of TheGirlfriend Doctor, we had a conversation with my very goodfriend/colleague of many years, Robin Nielsen. Robin is a hormoneexpert, Certified Clinical Nutritionist, and Board Certified inHolistic Health. Robin has been helping women with menopausalhealth for many years now and she gives us her secrets to maintaina healthy and thriving life!
Robin discusses the importanceon not only focusing on sex hormones because theyre minisculecompared to the other main hormones, which are cortisol andinsulin. She explains why that these are the main hormones womenshould focus on because they are the main factors that eithercontribute or deprive our gene expression. These factorsessentially control the trajectory of our success.
We also talk about her differentprograms made to help deal with the issues that come with menopauselike weight gain, mood destabilization, and more. Robin emphasizesthat ladies need to not only attend the hormone reset program butmaintain it after its done. Consistency is key when it comes torepairing our molecular integrity, and our lifestyle choices arethe formula. This talk is too interesting to not tune in, solisten, learn, and grow!
KEY TAKEAWAYS :
- Benefits of attendinghealth retreats
- Robin does not usesupplements in her hormone program
- What Robins hormonereset program consists of
- Where viewers can get ahold of Robin
Robins Hormone Reset:
MEMORABLE QUOTES:
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Are Your Hormones Wrecking Your Sex Drive With Robin Nielsen
In this episode Robin Neilsen and I jam on the hidden hormone deal breakers that may be wreaking havoc on your sex drive, what to look out for if you have a low sex drive, and how to be the Goddess of your goddess of your own health, as you hold the keys to your health and wellbeing and sexuality.
Robin is a Functional Nutritionist, Board Certified in Holistic Nutrition with over 13 years of clinical experience. She specializes in hormone balance and helping women grow younger no matter their age.
She is Founder and CEO of Insulite Health, PCOS.com the worlds most comprehensive company offering natural support to women with PCOS empowering them to take charge of their bodies, their health, and their lives.
As co-founder of Sexy Younger You!, she has launched 3 Summits and Programs and interviewed over 150 of the worlds leading health experts on the top strategies for aging well and balancing hormones. Robin is past president of the National Association of Women Business Owners, Silicon Valley, the National Association of Nutrition Professionals and her wellness retreats have been featured on the CBS program Eye on the Bay.
Do you suffer from unexplained weight gain, irregular menstrual cycles, facial hair or acne? Youre not alone and theres a solution.
Join the Natural Solutions for #PCOS online conference with 45 experts to take charge of your health. JOIN HERE!
or listen on Itunes or Stitcher.
Levothyroxine Therapy In Specific Subpopulations
6a.How should levothyroxine therapy be managed in the elderly with hypothyroidism?
Recommendation
In general, levothyroxine should be initiated with low doses, and the dose titrated slowly based on serum thyrotropin measurements. It should be recognized that normal serum thyrotropin ranges are higher in older populations , and that higher serum thyrotropin targets may be appropriate.
Strong recommendation. Moderate quality evidence.
Discussion of the clinical literature
In elderly persons who are without known heart disease or without major risk factors for heart disease, LT4 therapy can be initiated at the full dose , although the method of starting with a low dose and increasing it slowly is still preferred by some experts . The final LT4 dose that normalizes the serum TSH is generally lower in the elderly compared to younger persons , related to decreases in T4 turnover with age, in turn caused by decreases in lean body mass . However, other factors in the elderly, such as decreased thyroid hormone absorption concomitant drug use, which is more common in the elderly and other comorbidities may serve to negate the effects of decreased T4 metabolism, leading to an LT4 dose that is closer to what would be predicted in a younger person.
6b.How should levothyroxine therapy be managed in pregnant women with hypothyroidism?
Discussion of the clinical literature
6c.How should levothyroxine therapy be managed in infants and children with overt hypothyroidism?
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Levothyroxine And Other Nonhypothyroid Medical Conditions
5a.What is the appropriate management of perceived allergy to the constituents of levothyroxine or intolerance to levothyroxine?
Recommendation
Perceived allergy or intolerance to levothyroxine can be managed by changing the dose or product, including consideration of gel capsules, and possibly by treating concomitant iron-deficiency anemia. In selected cases, a consultation with an allergist may be appropriate.
Weak recommendation. Low-quality evidence.
Discussion of the clinical literature
5b.How do co-existent medical conditions affect the management of levothyroxine replacement therapy?
Recommendation
We recommend considering patients’ underlying medical conditions in order to establish realistic treatment goals and avoid exacerbation of underlying comorbidities.
Weak recommendation. Low-quality evidence.
Discussion of the clinical literature
Renal and liver disease
There are no adjustments in LT4 dosing that are required in cases of cirrhosis or renal failure. Nephrotic syndrome, with its large urinary protein losses that include the thyroid hormone transport proteins TBG, transthyretine and albumin, can be a cause of increased LT4 requirements due to excessive urinary thyroid hormone losses .
Cardiac disease
Gastrointestinal disease
See recommendation 3c for discussion of gastritis, celiac disease, and intestinal by-pass surgery
5c.How do co-existent psychosocial, behavioral, and mental health conditions affect the management of levothyroxine therapy?
Thyroid Hormone Analogs And Euthyroid Patients
23.Should thyroid hormone analog therapy be used in euthyroid individuals with nonhypothyroid-related medical conditions based on current evidence?
Recommendation
Although preclinical data suggest that the concept of thyromimetic use for treatment of nonhypothyroid-related medical conditions may be promising, we recommend against the use of such drugs outside of the research setting, due to concerns about the lack of clear benefit or excessive side effects of currently available preparations.
Strong recommendation. Low-quality evidence.
Mechanistic background
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Triiodothyronine Monotherapy For Hypothyroidism
14.Are there data regarding therapy with triiodothyronine alone, either as standard liothyronine or as sustained release triiodothyronine, that support the use of triiodothyronine therapy alone for the treatment of hypothyroidism?
Recommendation
Although short-term outcome data in hypothyroid patients suggest that thrice-daily synthetic liothyronine may be associated with beneficial effects on parameters such as weight and lipids, longer-term controlled clinical trials using a longer-acting form of triiodothyronine are needed before considering the endorsement of synthetic liothyronine therapy for routine clinical use.
Strong recommendation. Moderate quality evidence.
Mechanistic background
Discussion of the clinical literature
Although an extended-release formulation of LT3 has been shown in a single short-term study to reduce the peaks and troughs of LT3 administration that were seen over a 9-hour period after T3 administration , currently no formal pharmacokinetic study has been published. Presumably, once in the circulation as T3, the persistence of T3 is limited by its short half-life. Thus, even though a sustained release preparation may have reduced peaks and troughs, it may still need to be administered several times day. However, interestingly, a report of a sustained release profile for serum T3 levels after administration of a single dose of T3 sulfate to hypothyroid patients was recently published .