Saturday, February 24, 2024

Side Effects Of Estrogen Pill

Is Fatigue One Of The Effects Of High Estrogen Levels

What are the side effects of the mini pill?

Sometimes, people exhibit low levels of energy due to this hormone. If you are not sleeping well, you feel more fatigued and you need to bring your energy levels back to go on with your day. Feeling tired is normal for any human being after a difficult task but if you are exhausted more than usual and often showing low levels of energy without any reason then the effect of high estrogen may be the reason behind it.

Exacerbation Of Mental Health Problems

Estrogen is believed to have a protective effect on the brain. It appears to positively impact brain chemicals , cognition, and the ability to withstand stress. Dropping estrogen levels appear to be associated with an increased risk of psychosis. The age of menopause is associated with a second peak of schizophrenia onset in women. Results of preliminary research suggests selective estrogen receptor modulators may improve cognition and other symptoms in women who have psychiatric disorders. They may even reduce the frequency of manic episodes in women who have bipolar disorder. However, these drugs are not without potential risks. See your doctor if you believe decreasing estrogen levels are contributing to serious mental health symptoms.

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Whats The Difference Between Progestin And Estrogen In Birth Control Pills

When considering which oral contraceptive is right for you, two medical terms you might come across are progestin and estrogen. These refer to two female sex hormones that are used in birth control products. Outside of their use in contraceptives, estrogen and progesterone are naturally produced in the female body and play key roles in regulating certain body functions in women throughout puberty, pregnancy, and menopause.

As two common hormones found in oral contraceptives, understanding the differences between combination pills and progestin-only pills can help you select one that fits your needs and lifestyle. In this article, we will look at the major differences between progestin and estrogen as it relates to birth control, and why the pill is not one size fits all.

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What You Need To Know About Progestin

Progestin is a synthetic form of progesterone, which is a female hormone found in a womans body. As a naturally occurring hormone, progesterone is released from the ovaries to prepare the body for pregnancy. Progesterone also plays an important role during pregnancy. It contributes to maternal breast tissue growth while also preventing lactation, and prepares the body for labor by strengthening the wall muscles around the pelvic area.

Some common uses for progestin in products outside of contraception include treating abnormal uterine bleeding, severe premenstrual syndrome , and postmenopausal hormone replacement therapy.

Do progestin products have any adverse side effects? When taking oral contraceptives that contain progestin, some women may experience side effects including ovarian cysts, breast tenderness, headaches, fatigue, nausea, and hair thinning.

Other studies analyzing other side effects, such as the impact on sex drive and development of mood disturbances, are limited in terms of evidence and may offer conflicting views.

If youre experiencing any adverse side effects when taking oral contraceptives, make sure to talk to your doctor.

Youre Having Trouble Getting Pregnant

Pin on drug interactions and side effects

If youâre trying to get pregnant and you have low estrogen, it could be a challenge to conceive. This is connected to symptom #1 â if you donât have enough estrogen in your body for it to grow a thick uterine lining, you wonât have enough nourishment to grow a baby. Similarly, if youre not ovulating, your body isnt releasing an egg, meaning theres nothing for sperm to fertilize.

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More About Estrogen Patches


1. Auerbach R, Mittal K, Schwartz PE “Estrogen and progestin receptors in an ovarian ependymoma.” Obstet Gynecol 71 : 1043-5

2. Julian TM “Pseudoincontinence secondary to unopposed estrogen replacement in the surgically castrate premenopausal female.” Obstet Gynecol 70 : 382-3

3. “Product Information. Climara .” Berlex Laboratories :

4. “Product Information. Estrace .” Warner Chilcott Laboratories :

5. Nash HA, AlvarezSanchez F, Mishell DR, Fraser IS, Maruo T, Harmon TM “Estradiol-delivering vaginal rings for hormone replacement therapy.” Am J Obstet Gynecol 181 : 1400-6

6. Cerner Multum, Inc. “Australian Product Information.” O 0

7. “Product Information. Yuvafem .” AvKare Inc :

8. “Product Information. Estradiol Vaginal Insert .” Teva Pharmaceuticals USA :

9. Boston Collaborative Drug Surveilance Program “Surgically confirmed gallbladder disease, venous thromboembolism, and breast tumors in relation to postmenopausal estrogen therapy.” N Engl J Med 290 : 15-9

10. Crane MG, Harris JJ “Estrogens and hypertension: effect of discontinuing estrogens on blood pressure, exchangeable sodium, and the renin-aldosterone system.” Am J Med Sci 276 : 33-55

11. Crane MG, Harris JJ, Winsor W 3d “Hypertension, oral contraceptive agents, and conjugated estrogens.” Ann Intern Med 74 : 13-21

12. Rosenberg L, Slone D, Shapiro S, Kaufman D, Stolley PD, Miettinen OS “Noncontraceptive estrogens and myocardial infarction in young women.” JAMA 244 : 339-42

How Does This Medication Work What Will It Do For Me

Estradiol-17 belongs to the class of medications known as estrogen replacement therapy. Estrogen is a female hormone produced by the ovaries. Once menopause is reached, the ovaries produce less estrogen and progesterone , and symptoms of menopause can occur.

Estradiol-17 is an estrogen replacement hormone used to manage menopausal symptoms such as abnormal uterine bleeding, hot flashes, sweating, and chills.

It may also help to prevent osteoporosis for women when combined with diet, calcium, vitamin D, smoking cessation, and exercise. The decision to use this medication should be weighed against other options available for the treatment and prevention of osteoporosis.

Women who have not had a hysterectomy must also take a progestogen while they are taking this medication.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

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Possible Side Effects Of Ais

The most common side effects of AIs are:

  • Bone and joint pain

AIs tend to have side effects different from tamoxifen. They don’t cause uterine cancers and very rarely cause blood clots. They can, however, cause muscle pain and joint stiffness and/or pain. The joint pain may be similar to a feeling of having arthritis in many different joints at one time. Options for treating this side effect include, stopping the AI and then switching to a different AI, taking a medicine called duloxetine , or routine exercise with nonsteroidal anti-inflammatory drugs . But the muscle and joint pain has led some women to stop treatment. If this happens, most doctors recommend using tamoxifen to complete 5 to 10 years of hormone treatment.

Because AIs drastically lower the estrogen level in women after menopause, they can also cause bone thinning, sometimes leading to osteoporosis and even fractures. If you are taking an AI, your bone density may be tested regularly and you may also be given bisphosphonates or denosumab , to strengthen your bones.

Less Common Types Of Hormone Therapy

The effect of estrogen on the brain

Some other types of hormone therapy that were used more often in the past, but are rarely given now include:

  • Megestrol acetate , a progesterone-like drug
  • Androgens , like testosterone

These might be options if other forms of hormone therapy are no longer working, but they can often cause side effects.

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What Is Estradiol And How Does It Work

Estradiol is a female hormone . It is used by women to help reduce vaginal symptoms of menopause . These symptoms are caused by the body making less estrogen. When treating only vaginal symptoms of menopause, products applied directly inside the should be used first. Estrogens that are taken by mouth, absorbed through the skin, or injected may have greater risks of side effects due to more estrogen being absorbed.

Estradiol is available under the following different brand names: Estrace, Vivelle-Dot, Delestrogen, DepoEstradiol, Divigel, Elestrin, Alora, Estrace Cream, Estraderm Transdermal, estradiol topical, Estradot, Estrasorb, Estrogel, Evamist, Femtrace, Menostar, Minivelle, Vivelle, and Climara.

Increased Estrogen Can Cause Depression

Depression is a more complicated condition than people believe. Several mechanisms of action can pave the way to depression, and excess estrogen in men is one of them.

One study found that depressive symptoms were associated with depression in men, regardless of their BMI. This isnt such a surprise if we consider that as men age, they experience low testosterone , and estrogen increases.

Depression is often a common symptom of testosterone imbalance, including mood swings, irritability, among other things.

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Treatment Given Where It’s Needed

You can insert the Vagifem® 10 mcg insert with the slim applicator while standing up or lying down. You dont need to wash and reuse the applicator just dispose of it after use, as you would a tampon applicator. Learn more about how to take it, or read the complete instructions for taking Vagifem® in the Patient Information.

How To Avoid Estradiol Side Effects

Birth Control Pill Comparison Chart Side Effects Levonorgestrel and ...
  • Be sure you take estradiol exactly as prescribed and according to the drug information contained in the package insert. How often you take estradiol will depend on the form and your individual circumstances.
  • To avoid an upset stomach, you can take the oral form of estradiol with food or shortly after eating take it at the same time each day.
  • If you have been prescribed an extended-release version of estradiol, do not crush or chew the medication swallow it whole.
  • If you are using the gel form of estradiol, you can apply it at any time of the day, but be sure to do so at the same time each day to minimize side effects.
  • If you miss a dose and its more than 12 hours before your next dose, take the missed dose right away. Otherwise, skip the dose and wait until it is time to take your next one.
  • Take the minimum effective dose of estradiol. Your healthcare provider will monitor your progress every three to six months.
  • Because there may be an increased risk of breast cancer when taking the medication for prolonged periods of time, be sure to perform a monthly breast self-exam and stick to a yearly mammogram schedule.
  • Tell your healthcare provider about any persistent or unusual vaginal bleeding. You may need additional tests to find out the cause. You may also be given an additional hormone called a progestin to take together with estradiol.
  • Estradiol treatment is generally considered safe for a period of five years or less.
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    What Influences Appetite And Weight

    When Estrogen Drops, Hunger Increases

    A decrease in estrogen levels during a womans monthly cycle may trigger mood changes in some women. Some females may reach for comfort foods that are high in fat, calories, sugar, and salt in an effort to feel better. Sadly, eating these foods backfires and makes women feel worse. Sodium increases water retention and bloating. Sugar, excess fat and calories will lead you to pack on the pounds. Falling estrogen levels also affect leptin, a hormone that inhibits hunger. Combat hormonal weight gain by adopting a healthy diet and exercise plan. Stick to lean meats, healthy fats, complex carbs, whole grains, and fresh fruits and vegetables to help prevent PMS and encourage healthy blood sugar levels and weight loss.

    Why Does Your Estrogen Level Matter

    Estrogen is a hormone. Although present in the body in small amounts, hormones have big roles in maintaining your health.

    Estrogen is commonly associated with the female body. Men also produce estrogen, but women produce it in higher levels.

    The hormone estrogen:

    • is responsible for the sexual development of girls when they reach puberty
    • controls the growth of the uterine lining during the menstrual cycle and at the beginning of a pregnancy
    • causes breast changes in teenagers and women who are pregnant
    • is involved in bone and cholesterol metabolism
    • regulates food intake, body weight, glucose metabolism, and insulin sensitivity

    Girls who havent reached puberty and women approaching menopause are most likely to experience low estrogen. Still, women of all ages can develop low estrogen.

    Common symptoms of low estrogen include:

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    How Is Low Estrogen Treated

    Women who have low levels of estrogen may benefit from hormonal treatment. Hormonal treatment is the standard for low estrogen. There are non-hormonal options to help relieve symptoms. Non-hormonal options are preferred for women at high risk for breast cancer, blood clots, stroke, or liver disease.

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    Is Taking Estrogen Bad For You

    What are ethinyl estradiol & gestodene combined pills & its effectiveness? – Dr. Shailaja N

    Estrogen side effects and risks The risk factors and side effects associated with estrogen use include: Blood clots: Estrogen increases your risk of blood clots, which can cause stroke, heart attack, and even death. Cancer: Estrogen may increase your risk of certain cancers, specifically breast cancer.

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    Side Effects Of Progestogen

    The main side effects of taking progestogen include:

    • breast tenderness
    • vaginal bleeding

    As with side effects of oestrogen, these will usually pass after a few weeks.

    If they persist, a GP may recommend switching to a different way of taking progestogen, changing the medicine you’re taking, or lowering your dose.

    Major Health Risks Of Low Estrogen

    Osteoporosis. Estrogen helps maintain strong bones by preventing calcium loss. Too little calcium can increase the risk of fractures in the spine, hips, and leg and arm bones. Women who drink a lot of alcohol, who smoke, who are not active, and who are thin or petite are at greater risk. A family history of osteoporosis may also increase risk.

    Heart disease. Estrogen made by the body seems to protect against heart disease. It may do this by raising the level of HDL cholesterol in the blood. After menopause, the risk for heart disease rises sharply. Talk with your healthcare provider about ways to protect your heart health.

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    Amount Of Hormones In Low Dose Pills

    The most commonly used combination birth control pills contain between 30-35 micrograms of estrogen.

    These pills were actually once considered an extremely low dose because original formulations of birth control contained up to 150 micrograms of estrogen.

    However, modern low dose and ultra-low-dose formulations of combination birth control pills contain 20 or less micrograms of estrogen.

    These pills seem to be just as effective as regular birth control pills but cause fewer side effects from estrogen, such as bloating, tender breasts, and nausea.

    Many formulations are available for progestin-only oral contraceptives. One formulation contains 75 mcg of norgestrel. Another has 350 mcg of norethindrone.

    In 2019, a dosage of 4 mg of drospirenone was approved as a progestin-only oral contraceptive.

    Estrogenic Side Effects Background


    Estrogen side effects can refer both to the side effects that result from rising levels of Estrogen that originate from aromatization, or from estrogenic side effects that result from other causes that are not related to the rise in E2 . This is very important for the reader to understand, as Estrogen side effects can have numerous causes. The majority of the Estrogen side effects discussed here can all be treated with the use of anti-estrogens, which will be expanded upon a great deal in the next subsection of this article. The most common and prominent estrogenic side effects will be discussed here.

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    How Much Does It Cost

    • With insurance:Free under most plans
    • Without insurance: The full price of the pill can range from $10 – $113 a month. Depending on your income, you may be able to go to a low-cost clinic to get it at reduced cost.
    • Payment assistance: For brand-name pills, contact the manufacturers website for information about coupons and discounts. Or contact the Partnership for Prescription Assistance at 1-888-4-PPA-NOW or Also, check with your local family planning clinics and find out if they offer free or low-cost birth control pills .

    The Effects Of Low Estrogen

    Mood Swings

    Low estrogen levels in women are usually heralded by a variety of menopause symptoms. Low estrogen levels, are usually manifested by symptoms which can include:

    The importance of low estrogen symptoms is that while they may be grouped with normal hormonal changes and cycles, it can sometimes be an indication of more severe problems. Low estrogen can sometimes go unnoticed in many women and identifying the possible symptoms of low estrogen is of critical importance.

    Some ailments are important in assessing if a woman is potentially suffering from low estrogen levels. These include: depression, panic attacks, atherosclerosis, low self esteem, and vaginal infections. This mixture of mental and physical problems can be a major upheaval for many women.

    The upside of low estrogen symptoms is that once identified many of them can be easily treated.

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    What Are Warnings And Precautions For Estradiol



    • See “What Are Side Effects Associated with Using Estradiol?”

    Long-Term Effects

    • Increased risk of oral contraceptive use however human papillomavirus remains main risk factor for this cancer evidence suggests long-term use of OCs may be associated with increased risk.
    • Increased risk of liver cancer with OC use risk increases with longer duration of use
    • An increased risk of invasive breast cancer reported with estrogen plus progestin in WHI sub-study estrogens with or without progestins should be prescribed at lowest doses and for shortest duration
    • See “What Are Side Effects Associated with Using Estradiol?”


    Pregnancy and Lactation

    • Do not use estradiol in pregnancy
    • The risks involved outweigh potential benefits
    • Safer alternatives exist

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