Risks And Side Effects
HGH before and after pictures may be impressive, but remember that you should never buy human growth hormone for sale because not only is it illegal, but HGH should only be administered by a doctor.
Is HGH dangerous?
In its synthetic form it certainly can be very dangerous, especially when misused.
What are the negative effects of HGH? Side effects of HGH can include:
- Joint and muscle pain
- Swelling in the arms and legs
- For men, enlargement of breast tissue
Individuals also tend to notice their fingers feeling swollen or their faces feeling fuller at doses of four IU and above. This side effect is temporary and has been shown to go away when the dose is lowered within two weeks after the HGH cycle is discontinued.
According to Mayo Clinic, Human growth hormone might also contribute to conditions such as type 2 diabetes and heart disease and possibly an increased risk of some cancers.
Take A Gaba Supplement
Gamma aminobutyric acid is a non-protein amino acid that functions as a neurotransmitter, sending signals around your brain.
As a well-known calming agent for your brain and central nervous system, its often used to aid sleep. Interestingly, it may also help increase your HGH levels .
One study found that taking a GABA supplement led to a 400% increase in HGH at rest and a 200% increase following exercise .
GABA may also increase HGH levels by improving your sleep, since your nighttime growth hormone release is linked to sleep quality and depth (
52 ).
Another study demonstrated that a sugary sports drink increased HGH levels toward the end of a workout. However, if youre trying to lose fat, the drinks extra calories will negate any benefit from the short-term HGH spike .
Studies have shown that protein shakes both with and without carbs can boost HGH levels around workouts .
However, if a casein or whey protein supplement is taken immediately before strength exercise, it may have the opposite effect.
One study found that drinking a beverage containing 25 grams of casein or whey protein 30 minutes before strength exercise reduced levels of human growth hormone and testosterone, compared with a non-caloric placebo (
Try An Arginine Supplement
When taken alone, arginine may boost HGH.
Though most people tend to use amino acids like arginine alongside exercise, several studies show little or no increase in HGH levels .
However, studies have observed that taking arginine on its own without any exercise significantly increases levels of this hormone .
Other non-exercise studies also support the use of arginine to boost HGH.
One study examined the effects of taking either 45 or 114 mg of arginine per pound of body weight, or around 610 or 1520 grams per day, respectively.
It found no effect for the lower dose, but participants taking the higher dose experienced around a 60% increase in HGH levels during sleep (
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Hgh Doping And Athletic Performance
Adults who are GH deficient get larger muscles, more energy, and improved exercise capacity from replacement therapy. Athletes work hard to build their muscles and enhance performance. Some also turn to GH.
It’s not an isolated problem. Despite being banned by the International Olympic Committee, Major League Baseball, the National Football League, and the World Anti-Doping Agency, GH abuse has tainted many sports, including baseball, cycling, and track and field. Competitive athletes who abuse GH risk disqualification and disgrace. What do they gain in return? And do they also risk their health?
Because GH use is banned and athletic performance depends on so many physical, psychological, and competitive factors, scientists have been unable to evaluate GH on the field. But they can conduct randomized clinical trials that administer GH or a placebo to healthy young athletes and then measure body composition, strength, and exercise capacity in the lab.
A team of researchers from California conducted a detailed review of 44 high-quality studies of growth hormone in athletes. The subjects were young , lean , and physically fit 85% were male. A total of 303 volunteers received GH injections, while 137 received placebo.
If you were a jock in high school or college, you’re likely to wince at the memory of your coach barking “no pain, no gain” to spur you on. Today, athletes who use illegal performance-enhancing drugs risk the pain of disqualification without proof of gain.
The Intricate Role Of Growth Hormone In Metabolism
- Division of Endocrinology, Diabetes and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
Growth hormone , a master regulator of somatic growth, also regulates carbohydrate and lipid metabolism via complex interactions with insulin and insulin-like growth factor-1 . Data from human and rodent studies reveal the importance of GH in insulin synthesis and secretion, lipid metabolism and body fat remodeling. In this review, we will summarize the tissue-specific metabolic effects of GH, with emphasis on recent targets identified to mediate these effects. Furthermore, we will discuss what role GH plays in obesity and present possible mechanisms by which this may occur.
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Does Low Hgh Cause Anxiety
Young adults who were growth hormone deficient during childhood may have signs and symptoms of impaired physical and psychological well-being. These include feelings of depressed mood, emotional instability, social isolation, anxiety, low self-esteem and reduced vitality.
What are the effects of Hyposecretion?
What does IGF-1 do to the body?
IGF-1 is a hormone found naturally in your blood. Its main job is to manage the effects of growth hormone in your body. Normal IGF-1 and GH functions include tissue and bone growth. IGF-1 is formed in different tissues as a result of GH in the blood.
Hallmarks Of Aging: Decreased Hgh Muscle Mass And Functional Capacity
In both sexes, aging is accompanied by profound decreases in serum hGH and insulin-like growth factor-1 concentrations. This is caused by reduced activity in the area of the brain that produces GH-releasing hormone , the hormone that stimulates hGH production. At the same time, somatostatin productions increases, which further inhibits hGH production.
Typically, hGH levels decline from their peak during puberty to about one-tenth of that value by age 55. Circulating hGH levels are lower and stimulated hGH is blunted during aging.
The physical effects of reduced hGH levels are felt in a variety of ways depending on the individual:
- Quality of Sleep Reduction in the pattern of hGH sleep-related GH secretion resulting in loss of a clear night-day hGH rhythm.
- Body Composition The decline in GH production results in a decline in body mass index and is associated with changes in body composition, hormonal status, and functional capacity that mimic the changes seen in GHD.
- Bone Density and Reduced Muscle Mass Reduction in bone density, muscle mass and strength, parallel an increase in body fat and adverse changes in lipoprotein profiles are common. The decline in hGH production is not evident initially but over time contributes to sarcopenia and frailty as aging advances.
- Diminished Memory and Cognitive Function Deterioration of memory and cognitive function is commonly reported with decrease in hGH.
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Bring Down Sugar Level
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How We Diagnose Growth Hormone Deficiency
The first step in treating your child is forming an accurate and complete diagnosis. Before a growth hormone deficiency diagnosis can be made, your child’s physician may have to rule out other disorders first, including genetic short stature , inadequate caloric intake, thyroid hormone deficiency, and other illnesses, including gastrointestinal problems.
In addition to learning your child’s complete medical history, gathering information about the heights and any health problems of your relatives, and conducting a physical examination, your child’s doctor may:
- monitor your child’s growth over a period of time
- review the mother’s pregnancy, labor, and delivery
- draw a small amount of blood to look for evidence of other diseases
- arrange for an x-ray of your child’s hand and wrist
- measure amounts of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in the blood, which are produced when the liver and other tissues are stimulated by growth hormone
Since growth hormone is produced in bursts, it is unlikely that any single blood sample will provide a definitive diagnosis.
If growth hormone deficiency is suspected, your physician may use a stimulant of growth hormone secretion , and measure the growth hormone release over time.
If growth hormone deficiency is diagnosed, your physician may order an MRI of the brain to look at the hypothalamus and pituitary gland.
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What Causes Gh Deficiency In A Child
GH deficiency can be caused by damage to the pituitary gland or another gland called the hypothalamus. The injury can occur before birth , or during or after birth .
The pituitary gland is a pea-sized gland located at the base of the brain. Its the master endocrine gland in the body. The pituitary gland normally releases as many as 8 different hormones. These hormones control growth, metabolism, blood pressure, and other body processes.
In rare cases, GH deficiency can be part of a genetic syndrome. In many cases, the cause of GH deficiency is not known .
The Role Of Gh In Metabolism
Although GH’s main function is to promote growth in childhood, GH is still important once adulthood is reached. In adults as well as in children, GH helps regulate metabolism a critical chemical process through which the body turns food into energy, tissue or waste products. GH assists in transporting molecules, conserving sugars, building proteins, and breaking down fats. Not only is the GH produced in your body vital to maintaining healthy body composition, it also contributes to proper bone density, heart muscle function, and ratios of “good” to “bad” cholesterol, all of which are important to reduce the risk of such conditions as high cholesterol and osteoporosis.
Thus, like children, adults also need to maintain adequate levels of GH in the body. Without sufficient GH, adults have an increased risk of developing serious health problems, such as cardiovascular disease and bone disease, later in life.
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How Is Growth Hormone Controlled
Growth hormone release is not continuous it is released in a number of bursts or pulses every three to five hours. This release is controlled by two other hormones that are released from the hypothalamus : growth hormone-releasing hormone, which stimulates the pituitary to release growth hormone, and somatostatin, which inhibits that release.
Growth hormone levels are increased by sleep, stress, exercise and low glucose levels in the blood. They also increase around the time of puberty. Growth hormone release is lowered in pregnancy and if the brain senses high levels of growth hormone or insulin-like growth factors already in the blood.
What Is The Function Of Human Growth Hormone
Human growth hormone has two main functions: stimulating growth and impacting metabolism .
hGH and growth
Human growth hormone triggers growth in nearly every tissue and organ in your body. However, its most well-known for its growth-promoting effect on cartilage and bone, especially in the adolescent years during puberty. Cells in cartilage called chondrocytes and cells in bones called osteoblasts receive signals from hGH to increase replication and thus allow for growth in size.
Once the growth plates in a childs bones have fused, hGH no longer increases height. Instead, hGH helps to maintain normal body structure throughout the rest of your life.
hGH and metabolism
Metabolism consists of the chemical reactions in your body that change the food you eat into energy. All of the cells in your body need energy to function properly. Several different complex processes are involved in metabolism.
hGH impacts metabolism primarily by increasing the production of insulin-like growth factor-1 and its effect on cells in your body. IGF-1 is a hormone similar in structure to insulin that manages the effects of hGH in your body. Insulin is an essential hormone your pancreas makes that helps regulate your blood sugar levels by decreasing them. Like insulin, IGF-1 has glucose-lowering effects.
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Isolated Growth Hormone Deficiency
More than 70 mutations in the GH1 gene have been found to cause isolated growth hormone deficiency, a condition characterized by slow growth and short stature. Mutations that prevent the production of growth hormone, such as a deletion of a large section of the gene, result in isolated growth hormone deficiency type IA and severe growth failure by age 6 months. GH1 gene mutations that cause type IB are found throughout the gene and allow some growth hormone to be produced.
Most GH1 gene mutations that cause isolated growth hormone deficiency type II occur in a part of the gene called intron 3. These mutations result in the production of growth hormone that is shorter than normal. This short version of growth hormone is not released from cells and is not available to work in the body. In addition, this shorter growth hormone interferes with the function of normal growth hormone, so there is very little functional growth hormone available for use. A decrease in usable growth hormone results in the signs and symptoms of isolated growth hormone deficiency type II.
How Is Gh Deficiency Diagnosed In A Child
To diagnose GH deficiency, your childs healthcare provider needs to check for other conditions such as:
- Normal variations of growth, such as familial short stature
- Other disorders, such as thyroid hormone deficiency or kidney disease
- Genetic conditions
The healthcare provider will ask about your childs symptoms and health history and about your familys health history. He or she will also give your child a physical exam. Your child’s health and growth may be checked over several months.
Your child may also have tests, such as:
- Blood tests. These are done to check growth hormone and other related hormone levels. Sometimes the blood tests are done after your child is given a substance that would normally raise growth hormone levels.
- X-ray. This test uses a small amount of radiation to make images of tissues inside the body. An X-ray may be done of the left hand and wrist. This can estimate your child’s bone age. With delayed puberty or hormone problems, bone age is often less than calendar age.
- CT scan. This test uses a series of X-rays and a computer to make detailed images of the body. A CT scan can show bones, muscles, fat, and organs. CT scans are more detailed than regular X-rays.
- MRI. This test uses large magnets and a computer to make detailed images of tissues in the body.
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What Else Should I Know
Growth hormone can increase the speed of growth in a child with growth hormone deficiency. Kids who start this treatment early often can catch up more than kids who begin treatment later.
As adults, our bodies produce a much smaller amount of GH. So, many kids with GH deficiency and no other medical problems who get GH shots won’t need them as adults.
Symptoms Of Deficiency Of Growth Hormone
Any three of the below mentioned problems in the body are a reason for possible deficiency of growth hormone and one should get it checked by a good doctor:
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Which Children Are At Risk For Gh Deficiency
A child is more at risk for GH deficiency if he or she has any of these:
- Delayed puberty
It is important to note that GH deficiency does not affect the child’s intelligence.
The symptoms of GH deficiency can be like other health conditions. Make sure your child sees his or her healthcare provider for a diagnosis.
How Boston Childrens Hospital Approaches Growth Hormone Deficiency
We view the diagnosis of growth hormone deficiency as an important first step to treatment and, ultimately, to your childs long-term health and continued growth. You can rest assured knowing your child is in capable hands.
Our compassionate staff includes physician specialists who are experienced in the evaluation, diagnosis, and treatment of growth hormone deficiency. And we are uniquely qualified to determine the best course of care for your child. Our child-centric approach ensures that we care for your child as a child, not just another patient.
Because the chain of events involved in growth hormone deficiency is so complex, our researchers are investigating the different events that can cause a child to have short stature. Not all of these individual defects are well understood or easy to detect with a test, making this research vital to treatment strategies.
Our Division of Endocrinology is one of the world’s leading centers dedicated to caring for children and adolescents with acute and chronic endocrine and metabolic disorders. For children who suffer from growth problems, our dedicated team of doctors, nurses, and other caregivers offer hope for a healthier future.
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